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If increasing the dose in a particular patient does not lead to a further clinical response, it is possible that the maximum effect has been reached

However, this effect is transient and reversed upon discontinuation of therapy, and the long-term risk-benefit analysis of its administration is still unclear

Therefore, a man whose testosterone is pushed back up into the normal range by either SERMs, anastrazole, or HCG should have the same potential clinical benefit to sperm quality

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