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Brief summary To our knowledge, this is the first systematic review that stratifies outcomes by study design, exclusive e-cigarette use, and duration of e-cigarette exposure comparing e-cigarette users to non-smokers, traditional smokers, or dual-users, and assesses the certainty of evidence

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19 There were few dose reductions and temporary discontinuations (8% in varenicline group v 6% in placebo group) or permanent discontinuations (9% v 4%) because of adverse events (table 2)

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