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[] The common factor in all COVID-19-associated disorders appears to be disrupted redox (reductionoxidation system) homeostasis, which is associated with reactive oxygen species (ROS) deposition and is usually neutralized by antioxidants, the most common of which is glutathione (GSH) where it is produced in the liver from three amino acids (glycine, cysteine, and glutamate) and is vital for the immune system

Current research directions include investigations into glutathione's potential roles in neurodegenerative disease prevention and progression, cardiovascular disease risk modification, metabolic syndrome and diabetes management, cancer prevention and potentially as adjunct to certain cancer therapies, liver disease including fatty liver and cirrhosis, respiratory conditions including COPD and asthma, autoimmune and inflammatory conditions, and healthy aging and longevity optimization

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10.1016/j.cmet.2020.08.011 24 KimJ.JooJ