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This entails a progressive decline in the ability to manage levels of oxidative damage, which results in changes to cellular proteins, lipids and nucleic acids (Reference Bansal and Kaushal2)

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During this process, PLA particles were colonized by gut microbes, forming surface biofilms and increasing pullulanase activityan enzyme that degrades branched polysaccharidesthe authors suggested this may have broken down PLA into smaller carbon-rich molecules, potentially supporting Bifidobacterium growth, without triggering pathogenic overgrowth or inflammatory responses (Jimnez-Arroyo et al., 2023)