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Statements Author contributions BC: Writing original draft

These changes in the mature adipocytes defining characteristics compromise the models physiological relevance and prevent the ceiling culture technique from accurately replicating lipedema pathology over long-term culture

Elle initially trained in a different fat dissolving treatment, but decided not to take it up in to clinic due to the risk of treatment, the side effects and downtime associated with it, also finding it difficult to find the line between there being sufficient fat to make the patient appropriate for treatment, but not so much that they were precluded because they need to assume a healthier lifestyle and manage their weight

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