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CJC-1295 binds to the GHRH receptor to increase cAMP levels, priming the cell for hormone release, while Ipamorelin binds to the GHS-R1a receptor to amplify the depolarization and secretory signal

10.1097/00004647-199703000-00006 115 GrygorowiczT.StruzyskaL.SulkowskiG.ChalimoniukM.SulejczakD

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In this review, we, as a consensus panel of nephrologists experienced with HFR, survey existing literature and summarize our views on when to use this technique, which patients may be best suited for HFR, and how to effectively prescribe and monitor this modality of dialysis in daily clinical practice