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Free fatty acids act on receptors including GPR 43, GPR119 and GPR 120, and FFAR (29, 51, 113), and proteins may act through the Ca 2+ sensing receptor (CaSR) which responds to amino acids (24) or the peptide transporter PepT1 (69)
GLP-1s are here to stay
GLP-1 Receptor Pathway - Reduces hunger drive centrally (hypothalamus, brainstem) - Decreases the reward value of food (mesolimbic system) - Enhances glucose-dependent insulin secretion - Slows gastric emptying Amylin Receptor Pathway - Induces satiety through the area postrema and NTS - Activates POMC neurons (pro-satiety) and suppresses NPY/AgRP neurons (pro-hunger) in the arcuate nucleus - Additional gastric emptying delay through distinct neural circuits - Suppresses post-prandial glucagon secretion - May contribute to leptin resensitization The combination of these two pathways produces what researchers describe as broader modulation of neuroendocrine appetite control meaning amycretin hits more of the biological switches that drive eating behavior than a GLP-1-only drug can reach
Coverage for those drugs cost roughly $32 million this fiscal year but is expected to jump by 50 percent to more than $47 million next year, she wrote
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