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For example, HSPA1A can upregulate human polymerase III, thereby increasing tRNA synthesis, whereas HSC70, ER-related GRP78 and mitochondrial mortalin do not exert this type of activity (Leone et al., 2024)

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Factors that may trigger perioral dermatitis include the following: Drugs: steroid creams, ointments, and inhalers Fluorinated toothpaste Skincare lotions and creams, especially those containing petroleum jelly, paraffin base, and isopropyl myristate Sunscreens Makeup products Certain scented skincare products Ultraviolet (UV) light Heat Dust Wind Certain infections Oral contraceptives Hormones Vitamin B12 deficiency What are the signs of perioral dermatitis