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However, plasma concentration of citrulline, synthesized in the small intestinal epithelium as part of the urea cycle and serving as a functional readout of IEC mitochondrial function, was decreased in ClpP IEC mice, in line with previous results from Hsp60 IEC mice (64) ( Figure 5D )

In facial-photoaging research, topical application has been associated with increases in skin thickness, improvements in fine lines and wrinkles, and enhanced skin firmness