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Metformin also activates AMPK, the same pathway MOTS-C hits

There are are 4 planned TRIUMPH trials investigating retatrutide's efficacy in treating obesity and its complications: #type2diabetes #cardiovascular disease #osteoarthritis NEW Data drop at #ADA2023: Retatrutide, a triple agonist (GLP1, GIP, glucagon) lost an incredible 24.2% of their body weight, which amounts to 58 lbs

Patients with severe insulin resistance or strong family histories of type 2 diabetes sometimes respond better to tirzepatide's dual mechanism

But if your goal, as is the case in most dedicated research, is to explore the absolute maximum potential for tissue regeneration and recovery, the evidence strongly suggests that these two should be kept far apart