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Description

Icariin represses the inflammatory responses and survival of rheumatoid arthritis fibroblast-like synoviocytes by regulating the TRIB1/TLR2/NF-kB pathway

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More serious but less common adverse effects include pancreatitis, gallbladder disease (cholecystitis and cholelithiasis), and acute kidney injury, particularly in the setting of severe dehydration from gastrointestinal symptoms

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Glucagon suppression (reduces glucose production in the liver)

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However, bioavailability through topical application remains limited compared to injectable delivery

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