heart failure semaglutide Reduces Need for Diuretics in Patients Semaglutide and cardiovascular outcomes in

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3.3 Modulation of neuroendocrine signaling As a potential endocrine organ, the gut microbiota produces various metabolites with signaling functions or hormonal properties, including SCFAs, neurotransmitters, neuroactive compounds, bile acids, and choline metabolites

In addition, in the HepG2 cell experiment, some extrahepatic factors, such as erythroid-2-related factor 2 (NRF2) pathway [58], intestinal metabolite sodium butyrate (NaB) [59], Src homology region 2 domain-containing phosphatase-1 (SHP1)/AMPK [60], sirtuin 1 (SIRT1)/heat shock factor 1/heat shock protein (HSP) [61], and other signaling pathways have also been found to be involved in the regulation of liver lipid synthesis