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The incidence of hyperammonemia in pediatric patients 12 to 17 years of age in clinical trials of another condition was 26% in patients taking topiramate at 100 mg/day (1.1 times the maximum recommended dosage of phentermine and topiramate extended-release) and 14% in patients taking topiramate at 50 mg/day (0.6 times the maximum recommended dosage of phentermine and topiramate extended-release), compared to 9% in patients taking placebo

Table 1 gives a list of symptoms which were spontaneously described by patients in my withdrawal clinic

DPP-4 inhibitors: Linagliptin: hepatobiliary excretion (no dose adjustment required in patients with renal impairment, making it preferred) Other DPP-4 inhibitors (sitagliptin, vildagliptin, saxagliptin, and alogliptin) are predominantly eliminated by the kidneys, so dosage must be adjusted in cases of severe renal dysfunction

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