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In overdose, the increased formation of NAPQI depletes glutathione and once glutathione is depleted by more than two-thirds it covalently binds to critical cellular proteins

How treatment duration affects total spending Treatment duration determines cost escalation patterns

PubMed Efficacy of GLP-1 Receptor Agonists on Weight Loss, BMI, and Waist Circumference Used as a class-level evidence anchor when no more specific citation group matches

Covering even a fraction of those patients would come at a significant cost Congress estimates Medicare would spend about $35 billion between 2026 and 2034 under the proposed expansion