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Clearly, there has been a need for a new class of antidiabetic agents with advantages over currently marketed drugs that can lower glucose via mechanisms resulting in either neutral or protective effects on the cardiovascular system

Funding: The KDIGO guidelines are typically funded by KDIGO itself and not directly from pharma

To confirm whether Med14 was an integral link between GLP-1 drugs and ultimate changes in gene expression and pancreatic beta cell behavior, the researchers decided to mutate Med14, making the protein resistant to phosphorylation

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