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Because their mechanisms are so distinct, they could theoretically be part of a multi-faceted research protocol, though such complex studies demand even more rigorous control and careful interpretation of results

In vitro models isolate specific mechanisms like mitochondrial GSH depletion (Velsor et al., 2006) and Nrf2 dysfunction (Chen et al., 2008) under controlled conditions

Additionally, scientists observed increased activation of astrocytes and microglia, alongside reduced levels of the inflammatory cytokines IL-1 and TNF-, and increased levels of the anti-inflammatory cytokine IL-10[10]

| 2021 | Journal of the International Society of Sports Nutrition 3Bioavailability, Efficacy, Safety, and Regulatory Status of Creatine and Related Compounds: A Critical Review | Kreider et al