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Clinical outcomes in t(4;14) multiple myeloma: a chemotherapy-sensitive disease characterized by rapid relapse and alkylating agent resistance

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The inhibition of cancer cell growth by GLP-1RAs through regulating cAMP-dependent signaling GLP-1 receptor (GLP-1R) activation leads to adenylyl cyclase activation, subsequently inducing a substantial increase in intracellular cyclic adenosine monophosphate (cAMP) levels

FDA approval criteria (what your provider can prescribe): Type 2 diabetes, any BMI BMI 30+ for weight management BMI 27+ with weight-related comorbidity for weight management Typical commercial insurance coverage criteria (what insurers will pay for): Type 2 diabetes with A1C 7.0% or higher despite metformin therapy BMI 30+ (some plans require BMI 35+) Documented failure of at least one 3-month lifestyle intervention program No history of medullary thyroid carcinoma or MEN2 syndrome Pre-authorization approval from medical director The gap between FDA approval and insurance coverage creates a large population of medically eligible patients who can't access brand-name Mounjaro due to cost