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In rodents, modafinil, a wake-promoting drug that mediates dopamine-related psychostimulant action, prevented LPS-induced anxiety-like and depressive-like behaviors, as well as the LPS-induced increase in CD11b + CD45 high cells and IL-1 gene expression in the brain (Zager et al., 2018)

Research shows that IGF-1 DES does not bind very well to IGF-1 binding proteins (IGFBPs) found in the blood and in various tissues throughout the body

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