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Compounds derived from plants, marine organisms, and other natural sources, such as curcumin, resveratrol, and fucoidan, have demonstrated anti-inflammatory and immunomodulatory properties that may reduce immunosuppressive signals within the TME (184)

Licensed versus unlicensed prescribing Switching for non-formulary or intolerance reasons may constitute off-label use

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The landscape of heart failure (HF) management is evolving alongside a deeper understanding of how metabolic dysfunction drives cardiac pathology and the progression of HF, particularly in phenotypes like HF with preserved ejection fraction (HFpEF) associated with obesity