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We treated the slices with M-type K + channel blockers (10 M linopirdine+10 M XE991) prior to the application of Ex-4c, and we found that treatments by linopirdine and XE991 depolarized membrane potential in three of six cells (50%) by 3.91.7 mV (from 43.95.3 to 40.07.0 mV, n =3) (Fig