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Makinde Applied and Environmental Physiology Unit, Department of Physiology, University of Ibadan, Ibadan, Nigeria Correspondence to: A

Can NAC Support Energy and Brain Health in ME/CFS

useful for upper GI targeting Troches buccal absorption, limited evidence specific to BPC-157 Who oral delivery is best suited for: Leaky gut / intestinal permeability Inflammatory bowel disease (IBD, Crohn's, ulcerative colitis) NSAID-induced gastric damage or ulcers Irritable bowel syndrome (IBS) General GI maintenance alongside other therapies Patients who cannot or will not self-inject Practical considerations: Oral bioavailability is lower for systemic goals do not expect injection-equivalent tendon or joint results Dosing protocols typically require three to ten times the injectable dose to achieve comparable GI effects Product quality varies widely in the oral supplement market sourcing from a licensed compounding pharmacy is essential Nasal BPC-157: Emerging Option, Limited Evidence Nasal BPC-157 is the third delivery route and the least established

Somewhat surprisingly HDFA by itself does not appear to have a major significant effect on redox regulation or methylation pathways possibly because children were not pre-screened for low baseline GSH/GSSG