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The overwhelming dominance of ROS generated by enzymes like NADPH oxidases and xanthine oxidase over antioxidants like superoxide dismutase causes cell injury and tissue damage through direct injury, lipid peroxidation and protein oxidation leading to protease release and antioxidant and antiprotease enzyme inactivation as well as alteration of transcription factors activator protein-1 and NFB

Heat, light, and even physical agitation can act like hammers and wrenches, bending and breaking that delicate machinery

doi: 10.1152/ajpcell.00654.2023 117 QianFHuoD

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