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Given the complex mechanisms at play, it may be that in the overall population of adults with diabetes, GLP-1 RAs have minimal effects on GFR but may be more beneficial within specific subpopulations

However, in the context of a multi-agonist like retatrutide, its activation may have complex effects, potentially impacting energy expenditure and fat mobilization, balancing the overall metabolic effect

Trends Biochem Sci (2019) 44:40114

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