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The ZDHHC7 palmitoylates NLRP3 on Cys126, and thus mutation of NLRP3 Cys126 would disrupt its localization in the TGN as well as the recruitment and oligomerization of ASCs, inhibiting the activation of the inflammasome (71) ( Figure 3 )

Section II: Competitive Arena Overview Player Tier Map Player Summary Table Generate Competitive Landscape Reports Like This in Minutes Powered by Eureka LS AI Analyze patents, literature, and pipelines together Extract molecule & SAR data automatically Compare competitors and identify key assets Get structured reports instantly Section III: Approved Drug Landscape The approved GLP-1R drug portfolio has expanded rapidly, with 6 new approvals between 20242026 alone

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38 One classic metabolic reprogramming in tumors is the Warburg effect, 36,39,40,41 which is associated with lactate production