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dissolving 0.33g of the compound 1 in 100mL of acetonitrile, dropwise adding the mixture into the mixture, reacting at 0-5 for 3 hours, adjusting the pH of the obtained reaction liquid to 5.4 by using acetic acid, then adding 400mL of purified water, and centrifuging to obtain a solid compound 2, wherein the liquid chromatogram in the figure 1 shows that the purity of the compound 2 is 92.97%, the residual quantity of a raw material Arg34GLP-1 (9-37) is 3.74%, and double-modified impurities are not detected

M., et al., International Journal of Obesity , Vol

Although GLP-1RAs show promise in enhancing mitochondrial health, major gaps remain in understanding cell-type-specific responses, sex- and age-related differences, and the precise mechanistic links between GLP-1 signaling in mitochondrial biogenesis, dynamics, and mitophagy