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1 Their overlapping features include joint hypermobility, skin and vascular fragility, and generalized connective tissue friability 2 but the variability and clinical overlap can make the clinical diagnosis of a specific EDS subtype challenging

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In the early stages of atherosclerosis, macrophages bind to lipopolysaccharides to promote cholesterol accumulation, lipid accumulation in plaques, and foam cell formation, which is a hallmark of atherosclerotic lesions