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3.4.1 Inflammatory Markers IF has been linked to reducing systemic inflammation, as indicated by lowered circulating levels of significant inflammatory markers, including C-reactive protein (CRP) and interleukin-6 (IL-6) [63, 64]

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Bulk RNA-Seq data for 449 COAD samples were retrieved from the TCGA-COAD cohort ( while clinical and pathological information was obtained from UCSC Xena ( In this study, samples lacking complete clinical pathological data or with survival times of less than 1 month were excluded