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Collectively, evidence from both clinical studies and animal models (Table 4) demonstrates that while leptin supplementation is effective in cases of leptin deficiency, mutations in the leptin receptor, decreased receptor expression, or impairments in downstream signaling components result in leptin resistance, wherein exogenous leptin administration does not elicit meaningful weight-reducing effects

It has been reported that when ferroptosis occurs in neurons, then microglia are activated and release toxic substances including pro-inflammatory factor IL-6, which can cause neuro-inflammation and lead to further brain damage (Tang et al., 2020)

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