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The general mechanism of action of combined hormonal contraceptives (estrogens + progestogens) is based on the negative feedback that estrogens induce on the hypothalamus, inhibiting the secretion of gonadotropin release stimulating hormone (GnRH) and, consequently, preventing the increase in the secretion of gonadotrophins by the pituitary to stimulate ovulation in the middle of the cycle

Once fully dissolved, the solution should be clear and free of particles

Wound closure rate was evaluated by single-factor repeated measurement

Gently massage in circular motions, focusing on areas with pigmentation or dullness