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The SYNCHRONIZE-MASLD phase 3, randomized, double-blind, placebo-controlled trial included 216 adults (131 female and 85 male) with obesity (defined as a body mass index 30 kg m 2 or 27 kg m 2 with at least one obesity complication) and at-risk metabolic dysfunction-associated steatotic liver disease (MASLD), defined by MASLD with evidence of liver inflammation and/or fibrosis by noninvasive tests (NITs) or biopsy-confirmed metabolic dysfunction-associated steatohepatitis (MASH)
This proposed hierarchical framework requires validation through systematic metabolomic and functional studies to establish the relative contributions of different metabolites, thereby informing targeted therapeutic strategies (Figure 1)
However, it can indirectly alter your body scent due to metabolic shifts, rapid fat burning, delayed digestion, and dehydration
Nauck MA, Mgge A
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