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Additionally, the RNA-sequencing of L-Cn-treated PBMCs and the GSE62595 dataset can only show the transcriptome changes at the overall level, further studies on exploring the modulation mechanism of L-Cn on a single set of cells should be taken to dissect the related signaling pathway

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First of all, the study population was mainly from Iran, and the number of participants was small, so it needs to be further verified by increasing the sample size in future studies