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This review summarizes the molecular characteristics and antioxidant functions of GPX4, evaluates experimental evidence linking GPX4 and ferroptosis in OA, outlines upstream and downstream molecular mechanisms regulating GPX4, and summarizes therapeutic strategies targeting GPX4, including pharmacological, gene, and combination therapies

It's important to note, however, that dietary glutathione is not easily absorbed by the body

Although the exact mechanism of RA remains elusive, immune cells and fibroblast-like synoviocytes (FLS) are thought to be involved in its progression (129, 130)