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Studies have shown that patients on these medications, combined with lifestyle changes, can achieve substantial weight loss, often in the range of 15% to over 20% of their total body weight, making them a powerful tool in the fight against obesity

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2016 Sustained weight loss of 15.2% at week 104 with 2.4mg weekly

"These drugs are thought to work by engaging part of the brain called the hypothalamus, which helps regulate a wide variety of hormones," says Jena Shaw Tronieri, Senior Research Investigator at Penn's Center for Weight and Eating Disorders and a co-author of the study