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Description

Using spatial transcriptomics and single cell sequencing of MC38 tumor cells in mice treated with agonist anti-CD40 antibody therapy, it was demonstrated that heme-driven NRF2 activation in macrophages drives metabolic reprogramming towards immunosuppressive tumor associated macrophages (TAMs) [19]

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By cleverly combining response mechanisms to external stimuli (temperature, magnetic field, light) and internal stimuli (specific biomolecules, pH changes, redox potential), these nanoparticles can achieve intelligent drug release in complex and variable biological environments, thereby maximizing the therapeutic value of drugs during the treatment process [126]

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