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Additional alkyne-functionalized analogs of selected fragments ( 24 - 26 ) were synthe-sized and directly assessed for their ability to label proteins (Figure S4)

Interestingly, impaired vagal signaling may play a role in obesity, as decreased vagal activation to both mechanical stimuli and satiety-inducing signals is characteristic of a high-fat diet (HFD) 63,64,65,66

However, the slowed gastric emptying can also make the digestive system more sensitive to certain foods, particularly during the dose escalation phase