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A quantitative meta-analysis of vitamin C in the pathophysiology of Alzheimer's disease

Demonstrating that a purified protein stimulates GLP-1 release in isolated L cells is not the same as demonstrating that an oral probiotic capsule, after surviving stomach acid and reaching the colon, will colonize effectively and produce enough P9 to meaningfully increase systemic GLP-1 levels in a human being

Statements Author contributions LL had the idea for the article

However, plasma concentration of citrulline, synthesized in the small intestinal epithelium as part of the urea cycle and serving as a functional readout of IEC mitochondrial function, was decreased in ClpP IEC mice, in line with previous results from Hsp60 IEC mice (64) ( Figure 5D )