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Systemically, because it involves copper, there is a theoretical risk of copper overload with prolonged, high-dose use without proper cycling

Moreover, it is required for the transport and metabolism of fats and cholesterol, which is important for the healthy support of the endocrine, cardiovascular, and hepatic systems

Patients can also experience cognitive difficulties such as the ability to pay attention, concentrate, and focus on mental tasks

In research models, this inhibition indirectly preserves NAD by reducing methylation of nicotinamide, and also maintains SAM levels an effect precursors do not address