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The Endocrine Society's 2011 Clinical Practice Guideline on adult GH deficiency provides the diagnostic benchmarks most commonly used by compounding-protocol physicians

Given the importance of both methylation and de novo thymidylate biosynthesis processes and their obligate need to utilize 5,10-methyleneTHF, a strong rationale exists to examine genetic variation in key enzymes involved in both pathways in the context of the UVR influence on folate metabolism

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