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According to NICE guideline NG28 on type 2 diabetes management and the specific NICE Technology Appraisal for tirzepatide, GLP-1 receptor agonists like Mounjaro may be considered as part of a comprehensive treatment strategy when glycaemic targets are not achieved with other therapies or when weight loss would provide significant clinical benefit

Summary: GLP-1 receptor agonists are not specifically licensed for menopausal weight gain but may be prescribed for women meeting obesity treatment criteria (BMI 35 kg/m with comorbidities) during the menopausal transition

Genetic variation in GLP-1 receptor function, appetite-regulating pathways, and metabolic genes can influence the likelihood of meaningful weight loss and tolerability, suggesting a role for genetic screening in personalized assessment

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