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Maintenance, reduction, or withdrawal of etanercept after treatment with etanercept and methotrexate in patients with moderate rheumatoid arthritis (PRESERVE): a randomised controlled trial

A shower or bath the day after treatment is okay, but the treatment area should not be scrubbed

The authors reported that the combination was generally tolerated across the tested levels, with adverse events predominantly gastrointestinal and graded mild to moderate, and that the pharmacokinetic profile was consistent with once-weekly administration in the trial design

Denaturation unfolds the protein structure, potentially destroying the binding sites that make retatrutide effective at its three target receptors