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A variety of cellular stresses, including DNA damage can cause the induction of cellular senescence, which represents a multifaceted and highly heterogeneous cellular state characterized by irreversible growth arrest and importantly the secretion of a multitude of factors, including proteases and chemokines 2

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Headloss Rate (psi/day) = (Current Headloss Previous Headloss) / Days Since Last Backwash Example: Headloss last backwash: 2.0 psi Current headloss: 8.0 psi Days since last backwash: 10 Headloss Rate = (8.0 2.0) / 10 = 0.6 psi/day Sudden spikes in headloss rate