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The medication works by enhancing insulin secretion, suppressing glucagon release, slowing gastric emptying, and reducing appetite through central nervous system pathways

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Additionally, pattern recognition receptors like TLR2 and TLR4 on microglia can be chronically stimulated or desensitized by repetitive exposure to microbial MAMPs translocating from the gut, potentially affecting how microglia respond to misfolded proteins (either by over-reacting and causing bystander damage, or by entering a tolerant state that might impair clearance of aggregates) [71, 119]

On the one hand, immune cell infiltration is required to clear necrotic cells, initiate angiogenesis, and induce fibroblast growth