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Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics

This class of drugs is also immunomodulatory, especially in the context of cancer [35]

Filatova E, Kasian A, Kolomin T, et al (2017) GABA, selank, and olanzapine affect the expression of genes involved in gabaergic neurotransmission in IMR-32 Cells