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The most common complaints were nausea (55% versus 12.6% with placebo), constipation (30.7% versus 11.6%), and vomiting (26.1% versus 4.1%)

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Prolactin induced hypogonadism might contribute to the metabolic alterations in hyperprolactinemia

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Both reductive steps are catalysed by the enzyme dihydrofolate reductase

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