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What else your prescriber may ask about Alongside break length, previous dose, tolerance and reason for stopping, a thorough restart assessment may also cover: Any personal or family history of medullary thyroid carcinoma or MEN2 syndrome, which are contraindications to tirzepatide Any new medicines started during your break, including other diabetes treatments, oral contraceptives or medicines with a narrow therapeutic index Whether youve lost less than 5% of your initial body weight after 6 months at your highest tolerated dose in the past NICE guidance advises reviewing whether continued treatment remains appropriate in this situation Any planned surgery, anaesthesia or upcoming medical procedures What to verify before restarting with any provider Unregulated and counterfeit weight-loss medicines are a recognised patient-safety risk