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Our findings of increased serum palmitoyl-L-carnitine with aging are consistent with observations in heart failure and coronary artery disease [56], where elevated levels likely result from disrupted mitochondrial fatty acid oxidation and impaired -oxidation, leading to acylcarnitine accumulation [57]

Prostaglandin E2 (PGE2), a product of oxidative stress, is one of the most reliable biomarkers of lipid peroxidation in the human body, and of aging related diseases 67,68

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De Paiva CS, Villarreal AL, Corrales RM, Rahman HT, Chang VY, Farley WJ, Stern ME, Niederkorn JY, Li DQ, Pflugfelder SC: Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma