Intramuscular injections can be quite painful, particularly at the injection site, and may cause mild side effects such as diarrhea, temporary itching of the skin, and a sensation of swelling
(10) It outperformed the standard burn treatment, silver sulfadiazine, in some studies
GHK-Cu: The Gene Modulator Glycyl-L-histidyl-L-lysine-copper is a naturally occurring tripeptide that influences over 4,000 genes involved in tissue repair and inflammation resolution
MNA cells rely on an elevated antioxidant response through the Xc-/glutathione (GSH) pathway to scavenge lipid hydroperoxides, a by-product formed from excess H 2 O 2 ( We recently discovered in a drug screen that Diphenyleneiodonium chloride (DPI) selectively induces cell death of MNA NB cells in vitro and decreases tumor growth in vivo ( Although precision therapy for individual patients remains limited, combination therapy has the potential to enhance treatment efficacy while potentially reducing reliance on highly toxic chemotherapy ( 2 Results 2.1 MitoQ induces cell death and differentiation in neuroblastoma cells and potentiates DPI-induced cytotoxicity To investigate whether enhanced ROS production mediates the cytotoxic effects of DPI, we used MitoQ, a ROS scavenger that selectively accumulates in mitochondria ( Supplementary Figure S1 )
