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(NCBI) Think of GLP-1 signalling as an appetite brake + pacing system: Brain: appetite and reward modulation Gut: slower gastric emptying Pancreas: insulin secretion (glucose-dependent) and reduced glucagon secretion (context-dependent) The critical factor is that the lack of appetite typically leads to a caloric deficit

Prior to Wegovys approval for childhood obesity, there was another medication available

The effect of Roux-en-Y gastric bypass on bone marrow adipose tissue and bone mineral density in postmenopausal, nondiabetic women