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This body of work has included the study of foods such as olive oil [19], almonds [20] and red wine [21], as well as nutritional supplements containing vitamins and minerals [2224]

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Moreover, a recent randomized crossover study in healthy women demonstrated that prolonged mild sleep restriction markedly increased endothelial oxidative stress without activating compensatory antioxidant responses, due to reduced expression of DCUN1D3 gene, a regulator of the Nrf2-mediated antioxidant pathway, thereby suggesting a mechanistic link between insufficient sleep and vascular oxidative injury 78