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A Cochrane review in 2017 looked at the duration of pain and bruising after subcutaneous heparin injection and reported that a slow injection taking 30 seconds to administer may reduce pain but there is no difference in bruising compared with a fast injection (Mohammady, 2017)

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Along with resistance to treatment in some patients with glioblastoma, the inability to cross the bloodbrain barrier (BBB) is deemed another flaw of such methods of treatment [30]